Reddit user Redseve made a particularly compelling argument for it, saying that “the Empire and Thalmor would still be involved, people wanting the tensions to cease so Tamriel can focus on the plague, actors on both sides exploiting the chaos, would the Argonians be immune? Would they be rising in power? Dang this is a great idea”. Frickin’ Alduin, destroyer of worlds, has been defeated in Skyrim years before, and now a plague has broken loose in High Rock and has weakened all sides. Think about it: years after the signing of the White-Gold Concordat between the elven Aldmeri Dominion and the Empire, tensions are fraught. Including ‘-fall’ in the title seems like too much of a coincidence if you ask me, but it would make sense if Redfall became the name Bretons gave the red-skinned disease precisely because it started in one of Elder Scrolls 6’s locations, Daggerfall. Remember Daggerfall, the second game in the Elder Scrolls franchise that took place in High Rock? It could be the next piece of the puzzle when it comes to working out what that enigmatic term Redfall means. This next bit might be stretching slightly, but I’m going to go ahead with it anyway.

With some (ok, me) suspecting that Elder Scrolls 6 could be set in High Rock thanks to the coastline and craters in the brief 30-second teaser for the game we saw at E3, the mention of a terrible sickness beginning in High Rock could be setting up the pandemic that’s going to be featured in Elder Scrolls 6.

Tamriel redfall wikia